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Bioinformational attack on superfamily modelling and drug discovery

Date: 14.11.1997-31.12.2000
Code: 1682
Department: Åbo Akademi University / Faculty of Mathematics and Natural Sciences (MNF), Dept. of Biochemistry and Pharmacy
Address: BioCity, Artillerig. 6A /P.O. Box 66, FIN-20521 Åbo
Phone +358-2-2154 689
Fax +358-2-2154 745
E-mail Johnson@abo.fi
Project leader: Ph.D., Docent Mark Stuart Johnson, professor (1.1.1998-31.12.2000)
Type of research: 0 (0=Within duty, 1=Ordered research, 2=Co-operation)
- basic research 100 %
Finnish funding organizations: TEKES, Helsingfors (Gene research programme) FIM 1200000
Man months: Totally: 34 months
Keywords: proteiner, proteiinit, proteiners struktur, modeller för protein, sekvenser, proteinfamiljer, Protein structure, Protein modelling, sequences, Protein families,

To help us understand the criteria important to ligand and inhibitor binding within protein structures of medicinal value, we will develop a modelling tool aimed at deriving the most information from the entire related superfamily.This is a bioinformational approach that combines sequence information, 3D structural information, information from experimental studies, and novel clustering approaches.The result is the ability to pinpoint those features in a potential target drug that should provide specificity of binding to one member of the family, as opposed to them all.

Publication(s)

11.3.1996 / 12.6.1998