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Membrane vesiculation in human erythrocytes (Vesikulering hos erytrocyter)
| Date: | 1.10.1995- |
| Code: | 8652 |
| Department: | Åbo Akademi University / Faculty of Mathematics and Natural Sciences (MNF), Dept. of Biology |
| Address: |
BioCity, Artillerigatan 6, FIN-20520 Åbo
Phone +358-2-2154 060 Fax +358-2-2154 748 E-mail henry hagerstrand@abo.fi |
| Project leader: |
PhD Henry Hägerstrand, Forskare
(1.10.1995-) |
| Researchers: |
MSci Malgorzata Bobrowska-Hägerstrand (1.10.1995-) PhD Boris Isomaa (1.10.1995-) |
| Type of research: |
2 (0=Within duty, 1=Ordered research, 2=Co-operation)
- basic research 95 % - applied research 5 % |
| ÅA internal financing: | FIM 35000 |
| Finnish funding organizations: |
Oskar Öflunds stiftelse, Helsingfors () FIM Borgs stipendie fond () FIM |
| Man months: | Totally: 120 months |
| Partners: | Ales Iglic, University of Ljubljana, Slovenien Alexander Sikorski, University of Wroclaw, Polen |
| Contacts: | Samarbete med projektet Amphiphila ämnens effekter på membranrelaterade funktioner och processer |
| Keywords: | cellbiologi, solubiologia, erytrocyt, cellmembran, vesikulering, membranskelett, fosfolipidtranslokering, erythrocyte, cell membrane, membrane skeleton, membrane shedding, phospholipid translocation, |
Our aim is to clarify the molecular mechanisms responsible for the morphological and ultrastructural changes in amphiphile-treated erythrocytes undergoing vesiculation.One important part in this work will be to explore the impact of the membrane skeleton and its components on the vesiculation process.Another important part will be to clarify if changes in phospholipid distribution, phospholipid mobility or aminophospholipid-translocase activity are involved in the initiation or regulation of the vesiculation process.
16.2.1996 / 11.2.1998